Publications

  1. Caratti, G., Stifel, U., Caratti, B., Jamil, A.J.M., Chung, K.-J., Kiehntopf, M., Gräler, M.H., Blüher, M., Rauch, A., Tuckermann, J.P., 2023. Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance. Nat. Commun.14, 2271. https://doi.org/10.1038/s41467-023-37831-z (Open Access)
  2. Funcke, J.B., Möpps, B., Roos, J., von Schnurbein, J., Verstraete, K., Fröhlich-Reiterer, E., Kohlsdorf, K., Nunziata, A., Brandt, S., Tsirigotaki, A., Dansercoer, A., Suppen, E., Debatin, K.M., Savvides, S.N., Farooqi, I.S., Hussain, K., Gierschik, P., Fischer-Posovszky, P., Wabitsch, M., 2023. Rare antagonistic leptin variants and severe early-onset obesity. N. Engl. J. Med.Accepted.
  3. Miralles, A.J., Unger, N., Kannaiyan, N., Rossner, M.J., Dimou, L., 2023. Analysis of the GPR17 receptor in NG2-glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions. Glia71, 1536–1552. https://doi.org/10.1002/glia.24356 (Open Access)
  4. Parry, E.M., Leshchiner, I., Guièze, R., Johnson, C., Tausch, E., Parikh, S.A., Lemvigh, C., Broséus, J., Hergalant, S., Messer, C., Utro, F., Levovitz, C., Rhrissorrakrai, K., Li, L., Rosebrock, D., Yin, S., Deng, S., Slowik, K., Jacobs, R., Huang, T., Li, S., Fell, G., Redd, R., Lin, Z., Knisbacher, B.A., Livitz, D., Schneider, C., Ruthen, N., Elagina, L., Taylor-Weiner, A., Persaud, B., Martinez, A., Fernandes, S.M., Purroy, N., Anandappa, A.J., Ma, J., Hess, J., Rassenti, L.Z., Kipps, T.J., Jain, N., Wierda, W., Cymbalista, F., Feugier, P., Kay, N.E., Livak, K.J., Danysh, B.P., Stewart, C., Neuberg, D., Davids, M.S., Brown, J.R., Parida, L., Stilgenbauer, S*., Getz*, G.*, Wu, C.J*., 2023. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome.Nat. Med.29, 158–169. *Equally contributing senior authors. https://doi.org/10.1038/s41591-022-02113-6.
  5. Acharya, D., Reis, R., Volcic, M., Liu, G., Wang, M.K., Chia, B.S., Nchioua, R., Groß, R., Münch, J., Kirchhoff, F., Sparrer, K.M.J.*, Gack, M.U.*, 2022. Actin cytoskeleton remodeling primes RIG-I-like receptor activation. Cell185, 3588-3602.e21. https://doi.org/10.1016/j.cell.2022.08.011
    *Equally contributing senior authors.
  6. Pastorio, C., Zech, F., Noettger, S., Jung, C., Jacob, T., Sanderson, T., Sparrer, K.M.J., Kirchhoff, F., 2022. Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2. Cell Host Microbe30, 1255-1268.e5. https://doi.org/10.1016/j.chom.2022.07.006 (Open Access)
  7. Streit, L., Kuhn, T., Vomhof, T., Bopp, V., Ludolph, A.C., Weishaupt, J.H., Gebhardt, J.C.M., Michaelis, J., Danzer, K.M., 2022. Stress induced TDP-43 mobility loss independent of stress granules. Nat. Commun.13, 5480. https://doi.org/10.1038/s41467-022-32939-0 (Open Access)
  8. Gout, J., Perkhofer, L., Morawe, M., Arnold, F., Ihle, M., Biber, S., Lange, S., Roger, E., Kraus, J.M., Stifter, K., Hahn, S.A., Zamperone, A., Engleitner, T., Müller, M., Walter, K., Rodriguez-Aznar, E., Jr, B.S., Hermann, P.C., Hessmann, E., Müller, S., Azoitei, N., Lechel, A., Liebau, S., Wagner, M., Simeone, D.M., Kestler, H.A., Seufferlein, T., Wiesmüller, L., Rad, R., Frappart, P.-O., Kleger, A., 2021. Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.Gut 70, 743–760. https://doi.org/10.1136/gutjnl-2019-319970(Open Access)
  9. Köhler, A., Escher, B., Job, L., Koller, M., Thiermann, H., Skerra, A., Worek, F., 2021. Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro. Arch. Toxicol.95, 2815–2823. https://doi.org/10.1007/s00204-021-03094-0 (Open Access)
  10. Radamaker, L., Karimi-Farsijani, S., Andreotti, G., Baur, J., Neumann, M., Schreiner, S., Berghaus, N., Motika, R., Haupt, C., Walther, P., Schmidt, V., Huhn, S., Hegenbart, U., Schönland, S.O., Wiese, S., Read, C., Schmidt, M., Fändrich, M., 2021. Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM.Nat. Commun. 12, 6434. https://doi.org/10.1038/s41467-021-26553-9(Open Access)
  11. Philippi, A., Heller, S., Costa, I.G., Senée, V., Breunig, M., Li, Z., Kwon, G., Russell, R., Illing, A., Lin, Q., Hohwieler, M., Degavre, A., Zalloua, P., Liebau, S., Schuster, M., Krumm, J., Zhang, X., Geusz, R., Benthuysen, J.R., Wang, A., Chiou, J., Gaulton, K., Neubauer, H., Simon, E., Klein, T., Wagner, M., Nair, G., Besse, C., Dandine-Roulland, C., Olaso, R., Deleuze, J.-F., Kuster, B., Hebrok, M., Seufferlein, T., Sander, M., Boehm, B.O., Oswald, F., Nicolino, M., Julier, C., Kleger, A., 2021. Mutations and variants of ONECUT1 in diabetes. Nat. Med.27, 1928–1940. https://doi.org/10.1038/s41591-021-01502-7
  12. Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., El Ayoubi, O., Vogiatzi, F., Krämer, M., Schmid, V., Chen, Z., Yousafzai, Y., Cario, G., Schrappe, M., Müschen, M., Halsey, C., Mulaw, M.A., Schewe, D.M., Hobeika, E., Alsadeq, A., Jumaa, H., 2020. Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia.Nat. Commun. 11, 3194. https://doi.org/10.1038/s41467-020-16927-w(Open Access)
  13. Fischer, S., Ückert, A.-K., Landenberger, M., Papatheodorou, P., Hoffmann-Richter, C., Mittler, A.-K., Ziener, U., Hägele, M., Schwan, C., Müller, M., Kleger, A., Benz, R., Popoff, M.R., Aktories, K., Barth, H., 2020. Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT. FASEB J. 34, 6244–6261. https://doi.org/10.1096/fj.201902816R (Open Access)
  14. Florian, M.C., Leins, H., Gobs, M., Han, Y., Marka, G., Soller, K., Vollmer, A., Sakk, V., Nattamai, K.J., Rayes, A., Zhao, X., Setchell, K., Mulaw, M., Wagner, W., Zheng, Y., Geiger, H., 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell19, e13208. https://doi.org/10.1111/acel.13208 (Open Access)
  15. Gumpp, A.M., Boeck, C., Behnke, A., Bach, A.M., Ramo-Fernández, L., Welz, T., Gündel, H., Kolassa, I.-T., Karabatsiakis, A., 2020. Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc. Natl. Acad. Sci. U. S. A. 117, 24778–24784. https://doi.org/10.1073/pnas.2005885117
  16. Lutz, A.-K., Pfaender, S., Incearap, B., Ioannidis, V., Ottonelli, I., Föhr, K.J., Cammerer, J., Zoller, M., Higelin, J., Giona, F., Stetter, M., Stoecker, N., Alami, N.O., Schön, M., Orth, M., Liebau, S., Barbi, G., Grabrucker, A.M., Delorme, R., Fauler, M., Mayer, B., Jesse, S., Roselli, F., Ludolph, A.C., Bourgeron, T., Verpelli, C., Demestre, M., Boeckers, T.M., 2020. Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles. Sci. Transl. Med.12, eaaz3267. https://doi.org/10.1126/scitranslmed.aaz3267
  17. Meyer zu Reckendorf, S., Brand, C., Pedro, M.T., Hegler, J., Schilling, C.S., Lerner, R., Bindila, L., Antoniadis, G., Knöll, B., 2020. Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nat. Commun.11, 2123. https://doi.org/10.1038/s41467-020-15915-4 (Open Access)
  18. Thoms, M., Buschauer, R., Ameismeier, M., Koepke, L., Denk, T., Hirschenberger, M., Kratzat, H., Hayn, M., Mackens-Kiani, T., Cheng, J., Straub, J.H., Stürzel, C.M., Fröhlich, T., Berninghausen, O., Becker, T., Kirchhoff, F., Sparrer, K.M.J.*, Beckmann, R.*, 2020. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science 369, 1249–1255. https://doi.org/10.1126/science.abc8665(Open Access)
    *Equally contributing senior authors.
  19. Benkert, J., Hess, S., Roy, S., Beccano-Kelly, D., Wiederspohn, N., Duda, J., Simons, C., Patil, K., Gaifullina, A., Mannal, N., Dragicevic, E., Spaich, D., Müller, S., Nemeth, J., Hollmann, H., Deuter, N., Mousba, Y., Kubisch, C., Poetschke, C., Striessnig, J., Pongs, O., Schneider, T., Wade-Martins, R., Patel, S., Parlato, R., Frank, T., Kloppenburg, P., Liss, B., 2019. Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease. Nat. Commun.10, 5094. https://doi.org/10.1038/s41467-019-12834-x (Open Access)
  20. Haffner-Luntzer, M., Foertsch, S., Fischer, V., Prystaz, K., Tschaffon, M., Mödinger, Y., Bahney, C.S., Marcucio, R.S., Miclau, T., Ignatius, A., Reber, S.O., 2019. Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling. Proc. Natl. Acad. Sci.116, 8615–8622. https://doi.org/10.1073/pnas.1819218116
  21. Armacki, M., Trugenberger, A.K., Ellwanger, A.K., Eiseler, T., Schwerdt, C., Bettac, L., Langgartner, D., Azoitei, N., Halbgebauer, R., Groß, R., Barth, T., Lechel, A., Walter, B.M., Kraus, J.M., Wiegreffe, C., Grimm, J., Scheffold, A., Schneider, M.R., Peuker, K., Zeißig, S., Britsch, S., Rose-John, S., Vettorazzi, S., Wolf, E., Tannapfel, A., Steinestel, K., Reber, S.O., Walther, P., Kestler, H.A., Radermacher, P., Barth, T.F., Huber-Lang, M., Kleger, A., Seufferlein. T., 2018.  Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure. J. Clin. Invest.128, 5056–5072. doi: 10.1172/JCI97912 (Open Access)
  22. Denk, S., Neher, M.D., Messerer, D.A.C., Wiegner, R., Nilsson, B., Rittirsch, D., Nilsson-Ekdahl, K., Weckbach, S., Ignatius, A., Kalbitz, M., Gebhard, F., Weiss, M.E., Vogt, J., Radermacher, P., Köhl, J., Lambris, J.D., Huber-Lang, M.S., 2017. Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. J. Immunol.198, 4846–4854. https://doi.org/10.4049/jimmunol.1700393
  23. Kroner, J., Kovtun, A., Kemmler, J., Messmann, J.J., Strauss, G., Seitz, S., Schinke, T., Amling, M., Kotrba, J., Froebel, J., Dudeck, J., Dudeck, A., Ignatius, A., 2017. Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity. J. Bone Miner. Res.32, 2431–2444. https://doi.org/10.1002/jbmr.3234
  24. Wilfert, L., Long, G., Leggett, H.C., Schmid-Hempel, P., Butlin, R., Martin, S.J.M., Boots, M., 2016. Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science 351, 594–597. https://doi.org/10.1126/science.aac9976
  25. Wabitsch, M., Funcke, J.-B., Lennerz, B., Kuhnle-Krahl, U., Lahr, G., Debatin, K.-M., Vatter, P., Gierschik, P., Moepps, B., Fischer-Posovszky, P., 2015. Biologically Inactive Leptin and Early-Onset Extreme Obesity. N. Engl. J. Med.372, 48–54. https://doi.org/10.1056/NEJMoa1406653

Contact

Prof. Dr. med.
Markus Huber-Lang

markus.huber-lang@uniklinik-ulm.de

Prof. Dr. rer. med.
Alexander Kleger

alexander.kleger@uni-ulm.de

Prof. Dr.
Karin Danzer

karin.danzer@dzne.de

Jun. Prof.
Konstantin Sparrer

konstantin.sparrer@uni-ulm.de

Prof. Dr.
Pamela Fischer-​Posovszky

pamela.fischer@uniklinik-ulm.de